Abstract

Blood glucose monitor is a fundamental tool to maintain and control blood glucose levels for routine management of diabetes and complications associated with it. There have been continuous scientific advances and achievements in biosensors for the development of comprehensive glucose monitoring systems since last few decades. Portable, accurate, and reliable glucose monitoring devices with advanced features have been developed in recent years. However, invasive glucose monitors remained the most dominant devices on the market. Commercialization of clinically accurate and dependable non-invasive blood glucose monitoring devices still require rigorous works and further studies in sensor technologies. The aim of this article is to bring current updates and recent progress in electrochemical glucose sensing and non-invasive glucose monitoring techniques along with their merits and limitations. We present their key challenges and address future prospects of non-invasive glucose monitoring.

Keyword

Glucose, Electrochemical, Glucose monitoring, Non-invasive, Glucose monitors, Non-enzymatic.

Cite this article

Refference

[1][1]Nawaz A, Øhlckers P, Sælid S, Jacobsen M, Akram MN. Non-invasive continuous blood glucose measurement techniques. Journal of Bioinformatics and Diabetes. 2016; 1(3):1-27.

[2][2]Yadav J, Rani A, Singh V, Murari BM. Prospects and limitations of non-invasive blood glucose monitoring using near-infrared spectroscopy. Biomedical Signal Processing and Control. 2015; 18:214-27.

[3][3]Tian K, Prestgard M, Tiwari A. A review of recent advances in nonenzymatic glucose sensors. Materials Science and Engineering: C. 2014; 41:100-18.

[4][4]Vashist SK, Zheng D, Al-Rubeaan K, Luong JH, Sheu FS. Technology behind commercial devices for blood glucose monitoring in diabetes management: a review. Analytica Chimica Acta. 2011; 703(2):124-36.

[5][5]Toghill KE, Compton RG. Electrochemical non-enzymatic glucose sensors: a perspective and an evaluation. International Journal of Electrochemical Science. 2010; 5:1246-301.

[6][6]Lee H, Hong YJ, Baik S, Hyeon T, Kim DH. Enzyme based glucose sensor: from invasive to wearable device. Advanced Healthcare Materials. 2018; 7(8):1-14.

[7][7]Hammond JL, Formisano N, Estrela P, Carrara S, Tkac J. Electrochemical biosensors and nanobiosensors. Essays in Biochemistry. 2016; 60(1):69-80.

[8][8]Yoo EH, Lee SY. Glucose biosensors: an overview of use in clinical practice. Sensors. 2010; 10(5):4558-76.

[9][9]Vaddiraju S, Burgess DJ, Tomazos I, Jain FC, Papadimitrakopoulos F. Technologies for continuous glucose monitoring: current problems and future promises. Journal of Diabetes Science and Technology. 2010; 4(6):1540-62.

[10][10]Niraj GM, Varshney H, Pandey S, Singh S. Sensors for diabetes:glucose biosensors by using different newer techniques: a review. International Journal of Therapeutic Applications. 2012; 6:28-37.

[11][11]Bruen D, Delaney C, Florea L, Diamond D. Glucose sensing for diabetes monitoring: recent developments. Sensors. 2017; 17(8):1:21.

[12][12]Ghoreishizadeh SS, Zhang X, Sharma S, Georgiou P. Study of electrochemical impedance of a continuous glucose monitoring sensor and its correlation with sensor performance. IEEE Sensors Letters. 2018; 2(1):1-4.

[13][13]Yoon HS, Jeong SK, Xuan X, Park JY. Semi-implantable polyimide/PTFE needle-shaped biosensor for continuous glucose monitoring. In international conference on solid-state sensors, actuators and microsystems 2017 (pp. 1714-7). IEEE.

[14][14]Mikoliunaite L, Geceviciute M, Voronovic J, Paklonskait? I, Ramanaviciene JB, Ramanavicius A. Carbon nanostructures for electrochemical sensors. In international conference on nanomaterials: application and properties 2017. IEEE.

[15][15]Sakr MA, Serry M. Non-enzymatic graphene-based biosensors for continous glucose monitoring. In SENSORS 2015 (pp. 1-4). IEEE.

[16][16]Zhu C, Yang G, Li H, Du D, Lin Y. Electrochemical sensors and biosensors based on nanomaterials and nanostructures. Analytical Chemistry. 2014; 87(1):230-49.

[17][17]Wang G, He X, Wang L, Gu A, Huang Y, Fang B, et al. Non-enzymatic electrochemical sensing of glucose. Microchimica Acta. 2013; 180(3-4):161-86.

[18][18]Si P, Huang Y, Wang T, Ma J. Nanomaterials for electrochemical non-enzymatic glucose biosensors. RSC Advances. 2013; 3(11):3487-502.

[19][19]Zhang Y, Liu Y, Su L, Zhang Z, Huo D, Hou C, et al. CuO nanowires based sensitive and selective non-enzymatic glucose detection. Sensors and Actuators B: Chemical. 2014; 191:86-93.

[20][20]Huang J, Dong Z, Li Y, Li J, Wang J, Yang H, et al. High performance non-enzymatic glucose biosensor based on copper nanowires-carbon nanotubes hybrid for intracellular glucose study. Sensors and Actuators B: Chemical. 2013; 182:618-24.

[21][21]Hossain MF, Barman SC, Park JY. A highly performed nonenzymatic glucose sensor using surfactant template assisted platinum nanoparticles. In international conference on solid-state sensors, actuators and microsystems 2017 (pp. 1584-7). IEEE.

[22][22]Zhang X, Wang G, Huang Y, Yu L, Fang B. Non-enzymatic glucose detection using Ni/multi-walled carbon nanotubes composite. Micro & Nano Letters. 2012; 7(2):168-70.

[23][23]Huo H, Zhao Y, Xu C. 3D Ni 3 S 2 nanosheet arrays supported on Ni foam for high-performance supercapacitor and non-enzymatic glucose detection. Journal of Materials Chemistry A. 2014; 2(36):15111-7.

[24][24]Luo J, Jiang S, Zhang H, Jiang J, Liu X. A novel non-enzymatic glucose sensor based on Cu nanoparticle modified graphene sheets electrode. Analytica Chimica Acta. 2012; 709:47-53.

[25][25]Yin H, He X, Cui Z, Nie Q. Hollow Co3O4 microspheres assembled with nanocrystals for non-enzymatic glucose sensor. Micro & Nano Letters. 2016; 11(3):151-5.

[26][26]Klonoff DC. Overview of fluorescence glucose sensing: a technology with a bright future. Journal of Diabetes Science and Technology. 2012; 6(6):1242-50.

[27][27]Hull EL, Matter NI, Olson BP, Ediger MN, Magee AJ, Way JF, et al. Noninvasive skin fluorescence spectroscopy for detection of abnormal glucose tolerance. Journal of Clinical & Translational Endocrinology. 2014; 1(3):92-9.

[28][28]Stirban A. Noninvasive skin fluorescence spectroscopy for diabetes screening. Journal of Diabetes Science and Technology. 2013; 7(4):1001-4.

[29][29]Pickup JC, Khan F, Zhi ZL, Coulter J, Birch DJ. Fluorescence intensity-and lifetime-based glucose sensing using glucose/galactose-binding protein. Journal of Diabetes Science and Technology. 2013; 7(1):62-71.

[30][30]So CF, Choi KS, Wong TK, Chung JW. Recent advances in noninvasive glucose monitoring. Medical Devices (Auckland, NZ). 2012; 5:45-52.

[31][31]Pai PP, Sanki PK, Sahoo SK, De A, Bhattacharya S, Banerjee S. Cloud computing-based non-invasive glucose monitoring for diabetic care. IEEE Transactions on Circuits and Systems I: Regular Papers. 2018; 65(2):663-76.

[32][32]Al Naam HA, Idrees MO, Awad A, Abdalsalam OS, Mohamed F. Noninvasive blood glucose measurement based on photo-acoustic spectroscopy. In international conference on computing, control, networking, electronics and embedded systems engineering 2015 (pp. 1-4). IEEE.

[33][33]Vashist SK. Non-invasive glucose monitoring technology in diabetes management: a review. Analytica Chimica Acta. 2012; 750:16-27.

[34][34]Haxha S, Jhoja J. Optical based noninvasive glucose monitoring sensor prototype. IEEE Photonics Journal. 2016; 8(6):1-11.

[35][35]Losoya-Leal A, Camacho-Leon S, Dieck-Assad G, Martinez-Chapa SO. State of the art and new perspectives in non-invasive glucose sensors. Revista Mexicana De Ingeniería Biomédica. 2012; 33(1):41-52.

[36][36]Ansari RR, Boeckle S, Rovati LL. New optical scheme for a polarimetric-based glucose sensor. Journal of Biomedical Optics. 2004; 9(1):103-16.

[37][37]Romeo A, Moya A, Leung TS, Gabriel G, Villa R, Sánchez S. Inkjet printed flexible non-enzymatic glucose sensor for tear fluid analysis. Applied Materials Today. 2018; 10:133-41.

[38][38]Chowdhury MK, Srivastava A, Sharma N, Sharma S. Challenges & countermeasures in optical noninvasive blood glucose detection. International Journal of Innovative Research in Science, Engineering and Technology. 2013; 2(1):329-34.

[39][39]Amir O, Weinstein D, Zilberman S, Less M, Perl-Treves D, Primack H, et al. Continuous noninvasive glucose monitoring technology based on “occlusion spectroscopy”. Journal of Diabetes Science and Technology. 2007; 1(4):463-9.

[40][40]Tang F, Wang X, Wang D, Li J. Non-invasive glucose measurement by use of metabolic heat conformation method. Sensors. 2008; 8(5):3335-44.

[41][41]Jang S, Xu C. Review of emerging approaches in non- or minimally invasive glucose monitoring and their application to physiological human body fluids. International Journal of Biosensors & Bioelectronics. 2018; 4(1):5-9.

[42][42]Zhang Y, Zhu JM, Liang YB, Chen HB, Yin SM, Chen ZC. Non-invasive blood glucose detection system based on conservation of energy method. Physiological Measurement. 2017; 38(2):325-42.

[43][43]Alavi SM, Gourzi M, Rouane A, Nadi M. An original method for non-invasive glucose measurement: preliminary results. In proceedings of the international conference of the engineering in medicine and biology society 2001 (pp. 3318-20). IEEE.

[44][44]Tura A, Sbrignadello S, Barison S, Conti S, Pacini G. Impedance spectroscopy of solutions at physiological glucose concentrations. Biophysical Chemistry. 2007; 129(2-3):235-41.

[45][45]Sen K, Anand S. Design of microstrip sensor for noninvasive blood glucose monitoring. In international conference on emerging trends & innovation in ICT 2017 (pp. 5-8). IEEE.

[46][46]Xiao X, Li Q. A non-invasive measurement of blood glucose concentration by UWB microwave spectrum. IEEE Antennas and Wireless Propagation Letters. 2017; 16:1040-3.

[47][47]Ali MS, Shoumy NJ, Khatun S, Kamarudin LM, Vijayasarveswari V. Non-invasive blood glucose measurement performance analysis through UWB imaging. In international conference on electronic design 2016 (pp. 513-6). IEEE.

[48][48]Hofmann M, Bloss M, Weigel R, Fischer G, Kissinger D. Non-invasive glucose monitoring using open electromagnetic waveguides. In European microwave conference 2012 (pp. 546-9). IEEE.

[49][49]Turgul V, Kale I. A novel pressure sensing circuit for non-invasive RF/microwave blood glucose sensors. In mediterranean microwave symposium 2016 (pp. 1-4). IEEE.

[50][50]Shao J, Yang F, Xia F, Zhang Q, Chen Y. A novel miniature spiral sensor for non-invasive blood glucose monitoring. In European conference on antennas and propagation 2016 (pp. 1-2). IEEE.

[51][51]Tura A, Maran A, Pacini G. Non-invasive glucose monitoring: assessment of technologies and devices according to quantitative criteria. Diabetes Research and Clinical Practice. 2007; 77(1):16-40.

[52][52]Caduff A, Dewarrat F, Talary M, Stalder G, Heinemann L, Feldman Y. Non-invasive glucose monitoring in patients with diabetes: a novel system based on impedance spectroscopy. Biosensors and Bioelectronics. 2006; 22(5):598-604.

[53][53]Narasimham S, Kaila G, Anand S. Non-invasive glucose monitoring using impedance spectroscopy. International Journal of Biomedical Engineering and Technology. 2014; 14(3):225-32.

[54][54]Hillier TA, Abbott RD, Barrett EJ. Hyponatremia: evaluating the correction factor for hyperglycemia. The American Journal of Medicine. 1999; 106(4):399-403.

[55][55]Polevaya Y, Ermolina I, Schlesinger M, Ginzburg BZ, Feldman Y. Time domain dielectric spectroscopy study of human cells: II. normal and malignant white blood cells. Biochimica Biophysica Acta (BBA)-Biomembranes. 1999; 1419(2):257-71.

[56][56]Liu Y, Xia M, Nie Z, Li J, Zeng Y, Wang L. In vivo wearable non-invasive glucose monitoring based on dielectric spectroscopy. In international conference on signal processing 2016 (pp. 1388-91). IEEE.

[57][57]Tamada JA, Bohannon NJ, Potts RO. Measurement of glucose in diabetic subjects using noninvasive transdermal extraction. Nature Medicine. 1995; 1(11):1198-201.

[58][58]Bandodkar AJ, Jia W, Yardımcı C, Wang X, Ramirez J, Wang J. Tattoo-based noninvasive glucose monitoring: a proof-of-concept study. Analytical Chemistry. 2014; 87(1):394-8.

[59][59]Lin T, Gal A, Mayzel Y, Horman K, Bahartan K. Non-invasive glucose monitoring: a review of challenges and recent advances. Current Trends in Biomedical Engineering & Biosciences. 2017; 6(5):1-8.

[60][60]Chuang H, Taylor E, Davison TW. Clinical evaluation of a continuous minimally invasive glucose flux sensor placed over ultrasonically permeated skin. Diabetes Technology & Therapeutics. 2004; 6(1):21-30.

[61][61]Lin T, Mayzel Y, Bahartan K. The accuracy of a non-invasive glucose monitoring device does not depend on clinical characteristics of people with type 2 diabetes mellitus. Journal of Drug Assessment. 2018; 7(1):1-7.

[62][62]Segman Y. Device and method for noninvasive glucose assessment. Journal of Diabetes Science and Technology. 2018.

[63][63]Pfützner A, Strobl S, Demircik F, Redert L, Pfützner J, Pfützner AH, et al. Evaluation of a new noninvasive glucose monitoring device by means of standardized meal experiments. Journal of Diabetes Science and Technology. 2018.

[64][64]Freckmann G, Schmid C, Baumstark A, Pleus S, Link M, Haug C. System accuracy evaluation of 43 blood glucose monitoring systems for self-monitoring of blood glucose according to DIN EN ISO 15197. Journal of Diabetes Science and Technology. 2012; 6(5):1060-75.

[65][65]Freckmann G, Baumstark A, Jendrike N, Zschornack E, Kocher S, Tshiananga J, et al. System accuracy evaluation of 27 blood glucose monitoring systems according to DIN EN ISO 15197. Diabetes Technology & Therapeutics. 2010; 12(3):221-31.

[66][66]Rodbard D. Continuous glucose monitoring: a review of successes, challenges, and opportunities. Diabetes Technology & Therapeutics. 2016; 18(S2):3-13.

[67][67]Makaram P, Owens D, Aceros J. Trends in nanomaterial-based non-invasive diabetes sensing technologies. Diagnostics. 2014; 4(2):27-46.

[68][68]Sobel SI, Chomentowski PJ, Vyas N, Andre D, Toledo FG. Accuracy of a novel noninvasive multisensor technology to estimate glucose in diabetic subjects during dynamic conditions. Journal of Diabetes Science and Technology. 2014; 8(1):54-63.

[69][69]Xiong F, Hipszer BR, Joseph J, Kam M. Improved blood glucose estimation through multi-sensor fusion. In international conference of the engineering in medicine and biology society 2011 (pp. 377-80). IEEE.

[70][70]Yadav J, Rani A, Singh V, Murari BM. Investigations on multisensor-based noninvasive blood glucose measurement system. Journal of Medical Devices. 2017; 11(3).

[71][71]Geng Z, Tang F, Ding Y, Li S, Wang X. Noninvasive continuous glucose monitoring using a multisensor-based glucometer and time series analysis. Scientific Reports. 2017; 7:1-10.

[72][72]Asaduzzaman A, Samadarsinee S, Chidella KK. Simulating multisensor noninvasive blood glucose monitoring systems. In Southeastcon 2016 (pp. 1-7). IEEE.

[73][73]Zanon M, Sparacino G, Facchinetti A, Talary MS, Mueller M, Caduff A, et al. Non-invasive continuous glucose monitoring with multi-sensor systems: a Monte Carlo-based methodology for assessing calibration robustness. Sensors. 2013; 13(6):7279-95.

[74][74]Fischbacher C, Jagemann KU, Danzer K, Muller UA, Papenkordt L, Schuler J. Enhancing calibration models for non-invasive near-infrared spectroscopical blood glucose determination. Fresenius Journal of Analytical Chemistry. 1997; 359(1):78-82.

[75][75]Muller UA, Mertes B, Fischbacher C, Jageman KU, Danzer K. Non-invasive blood glucose monitoring by means of near infrared spectroscopy: methods for improving the reliability of the calibration models. The International Journal of Artificial Organs. 1997; 20(5):285-90.

[76][76]Ramasahayam S, Koppuravuri SH, Arora L, Chowdhury SR. Noninvasive blood glucose sensing using near infra-red spectroscopy and artificial neural networks based on inverse delayed function model of neuron. Journal of Medical Systems. 2015; 39.

[77][77]Savage MB, Kun S, Harjunmaa H, Peura RA. Development of a non-invasive blood glucose monitor: application of artificial neural networks for signal processing. In proceedings of the bioengineering conference 2000 (pp. 29-30). IEEE.

[78][78]Stemmann M, Stahl F, Lallemand J, Renard E, Johansson R. Sensor calibration models for a non-invasive blood glucose measurement sensor. In international conference of the engineering in medicine and biology society 2010 (pp. 4979-82). IEEE.

[79][79]Cinar A, Turksoy K. Modeling glucose and insulin concentration dynamics. In advances in artificial pancreas systems 2018 (pp. 33-50). Springer, Cham.