Abstract

Tissue engineering is an interesting field. The tissue engineering scaffold allows the delivery of cells and growth factors to the damaged part of the body to allow for the regeneration of tissue. This work aimed to evaluate polycaprolactone (PCL) blended with carboxymethylcellulose (CMC) composite scaffolds. The porous scaffolds were created using the salt leaching process. An experimental technique was used to characterize the mechanical characteristics of the scaffolds. We evaluated the modeling by describing the stress-strain behavior of the scaffolds using the neo-Hookean model. The shear modulus of the polycaprolactone scaffold containing 2, 11, 15.5, and 20% CMC was 0.074, 0.037, 0.034, and 0.085 megapascal (MPa), respectively. A scaffold with a PCL/CMC ratio of 93.5/6.5 had the highest average shear modulus of 0.245 MPa when compared to other mixed scaffolds. There was a significant difference when compared to a pure polycaprolactone scaffold. The result could provide excellent conditions for creating scaffolds for use in cell transplantation and culture.

Keyword

Polycaprolactone, Carboxymethylcellulose, Compressive modulus, Shear modulus, Neo-hookean model.

Cite this article

Sriputtha N, Wiwatwongwana F, Promma N

Refference

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