International Journal of Advanced Technology and Engineering Exploration (IJATEE) ISSN (P): 2394-5443 ISSN (O): 2394-7454 Vol - 10, Issue - 104, July 2023
  1. 1
    Google Scholar
Automatic detection of infected areas of CT images in COVID-19 patients using Inf-Seg-Net

J. Kalaivani and A.S. Arunachalam

Abstract

The swift spread of the coronavirus disease (COVID-19) makes it extremely difficult for early detection and diagnosis of the virus, necessitating timely care. Numerous research institutes, laboratories, diagnostic facilities, non-governmental organizations, and government-funded organizations collaborate daily to identify challenges that arise throughout the COVID-19 virus detection procedure. The first screening method utilized to locate COVID-19 was reverse transcription polymerase chain reaction (RT-PCR). However, advancements in technology have paved the way for the use of computed tomography (CT) imaging in early screening. Radiologists and research scientists are now exploring the potential of artificial intelligence (AI) and deep learning (DL) techniques to develop an automated disease detection model utilizing CT images for screening purposes. The aim of this research is to simplify infection segmentation by using Inf-Seg-Net, a network-based technique with dense UNets and residual blocks for infection classification. The proposed framework involves three stages: preprocessing CT images using contrast limited adaptive histogram equalization based on non-local mean filter (CLAHEN), followed by logarithmic non-maxima suppression (LNMS) for lung segmentation, and an infection segmentation network (Inf-Seg-Net) for infection classification. In this study, various DL models, including ResNet, SegNet, and UNet, were evaluated for their effectiveness in diagnosing COVID-19 infection using a real-time dataset of lung CT images. The proposed Inf-Seg-Net model demonstrated promising results, providing high-quality masking on the lung segmentation images. It achieved remarkable performance metrics, including 98.06% accuracy, 96.15% Jaccard index, 100% sensitivity, 98.1% precision, and 98.73% F1 score, indicating its potential for detecting infections from CT scans and outperforming existing models. These findings highlight the potential of AI and DL techniques in enhancing COVID-19 diagnosis and pave the way for more efficient and accurate screening methods.

Keyword

COVID-19, CT images, Deep learning, Infection segmentation.

Cite this article

Kalaivani J, Arunachalam A

Refference

[1][1]Ranjbarzadeh R, Jafarzadeh GS, Bendechache M, Amirabadi A, Ab MN, Baseri SS, et al. Lung infection segmentation for COVID-19 pneumonia based on a cascade convolutional network from CT images. BioMed Research International. 2021; 2021:1-6.

[2][2]Hamzenejad A, Jafarzadeh GS, Baradaran V, Mardani A. A robust algorithm for classification and diagnosis of brain disease using local linear approximation and generalized autoregressive conditional heteroscedasticity model. Mathematics. 2020; 8(8):1-19.

[3][3]Chen J, Wu L, Zhang J, Zhang L, Gong D, Zhao Y, et al. Deep learning-based model for detecting 2019 novel coronavirus pneumonia on high-resolution computed tomography. Scientific Reports. 2020; 10(1):1-11.

[4][4]Wang G, Liu X, Li C, Xu Z, Ruan J, Zhu H, et al. A noise-robust framework for automatic segmentation of COVID-19 pneumonia lesions from CT images. IEEE Transactions on Medical Imaging. 2020; 39(8):2653-63.

[5][5]Rubin GD, Ryerson CJ, Haramati LB, Sverzellati N, Kanne JP, Raoof S, et al. The role of chest imaging in patient management during the COVID-19 pandemic: a multinational consensus statement from the Fleischner Society. Radiology. 2020; 296(1):172-80.

[6][6]Ranjbarzadeh R, Saadi SB. Automated liver and tumor segmentation based on concave and convex points using fuzzy c-means and mean shift clustering. Measurement. 2020; 150:107086.

[7][7]Dhall A, Patiyal S, Sharma N, Usmani SS, Raghava GP. Computer-aided prediction and design of IL-6 inducing peptides: IL-6 plays a crucial role in COVID-19. Briefings in Bioinformatics. 2021; 22(2):936-45.

[8][8]Ahmadi M, Sharifi A, Dorosti S, Ghoushchi SJ, Ghanbari N. Investigation of effective climatology parameters on COVID-19 outbreak in Iran. Science of the Total Environment. 2020; 729:138705.

[9][9]Ronneberger O, Fischer P, Brox T. U-net: convolutional networks for biomedical image segmentation. In 18th international conference on medical image computing and computer-assisted intervention 2015 (pp. 234-41). Springer International Publishing.

[10][10]Kong L, Cheng J. Classification and detection of COVID-19 X-Ray images based on DenseNet and VGG16 feature fusion. Biomedical Signal Processing and Control. 2022; 77:103772.

[11][11]He K, Zhang X, Ren S, Sun J. Deep residual learning for image recognition. In proceedings of the IEEE conference on computer vision and pattern recognition 2016 (pp. 770-8). IEEE.

[12][12]Shen S, Bui AA, Cong J, Hsu W. An automated lung segmentation approach using bidirectional chain codes to improve nodule detection accuracy. Computers in Biology and Medicine. 2015; 57:139-49.

[13][13]Jin D, Xu Z, Tang Y, Harrison AP, Mollura DJ. CT-realistic lung nodule simulation from 3D conditional generative adversarial networks for robust lung segmentation. In 21st international conference on medical image computing and computer assisted intervention 2018 (pp. 732-40). Springer International Publishing.

[14][14]Wang S, Kang B, Ma J, Zeng X, Xiao M, Guo J, et al. A deep learning algorithm using CT images to screen for corona virus disease (COVID-19). European Radiology. 2021; 31:6096-104.

[15][15]Shi F, Xia L, Shan F, Song B, Wu D, Wei Y, et al. Large-scale screening to distinguish between COVID-19 and community-acquired pneumonia using infection size-aware classification. Physics in Medicine & Biology. 2021; 66(6):065031.

[16][16]Diniz JO, Quintanilha DB, Santos NAC, Da SGL, Ferreira JL, Netto SM, et al. Segmentation and quantification of COVID-19 infections in CT using pulmonary vessels extraction and deep learning. Multimedia Tools and Applications. 2021; 80(19):29367-99.

[17][17]Yao Q, Xiao L, Liu P, Zhou SK. Label-free segmentation of COVID-19 lesions in lung CT. IEEE Transactions on Medical Imaging. 2021; 40(10):2808-19.

[18][18]Gao K, Su J, Jiang Z, Zeng LL, Feng Z, Shen H, et al. Dual-branch combination network (DCN): Towards accurate diagnosis and lesion segmentation of COVID-19 using CT images. Medical Image Analysis. 2021; 67:101836.

[19][19]Jeevitha S, Valarmathi K. A joint segmentation and classification framework for COVID‐19 infection segmentation and detection from chest CT images. International Journal of Imaging Systems and Technology. 2023; 33(3):789-806.

[20][20]Kordnoori S, Sabeti M, Mostafaei H, Banihashemi SS. Analysis of lung scan imaging using deep multi‐task learning structure for Covid‐19 disease. IET Image Processing. 2023; 17(5):1534-45.

[21][21]Roy S, Das AK. Deep‐CoV: an integrated deep learning model to detect COVID‐19 using chest X‐ray and CT images. Computational Intelligence. 2023; 39(2):369-400.

[22][22]Patel RK, Kashyap M. Automated diagnosis of COVID stages using texture‐based gabor features in variational mode decomposition from CT images. International Journal of Imaging Systems and Technology. 2023; 33(3):807-21.

[23][23]Kannan G, Karunambiga K, Sathish KPJ, Shajin FH. Detection of COVID‐19 patient based on attention segmental recurrent neural network (ASRNN) Archimedes optimization algorithm using ultra‐low‐dose CT images. Concurrency and Computation: Practice and Experience. 2023:e7705.

[24][24]Abualigah L, Diabat A, Sumari P, Gandomi AH. A novel evolutionary arithmetic optimization algorithm for multilevel thresholding segmentation of covid-19 CT images. Processes. 2021; 9(7):1-37.

[25][25]Ilhan A, Alpan K, Sekeroglu B, Abiyev R. COVID-19 lung CT image segmentation using localization and enhancement methods with U-Net. Procedia Computer Science. 2023; 218:1660-7.

[26][26]Suvathi T, Chandrasekar A, Thanaraj KP. Deep learning based lung segmentation prior for robust COVID-19 classification. In international conference on artificial intelligence and knowledge discovery in concurrent engineering 2023 (pp. 1-5). IEEE.

[27][27]Jyoti K, Sushma S, Yadav S, Kumar P, Pachori RB, Mukherjee S. Automatic diagnosis of COVID-19 with MCA-inspired TQWT-based classification of chest X-ray images. Computers in Biology and Medicine. 2023; 152:1-11.

[28][28]Jia H, Tang H, Ma G, Cai W, Huang H, Zhan L, et al. A convolutional neural network with pixel-wise sparse graph reasoning for COVID-19 lesion segmentation in CT images. Computers in Biology and Medicine. 2023; 155:1-11.

[29][29]Gupta K, Bajaj V. Deep learning models-based CT-scan image classification for automated screening of COVID-19. Biomedical Signal Processing and Control. 2023; 80:1-9.

[30][30]Constantinou M, Exarchos T, Vrahatis AG, Vlamos P. COVID-19 classification on chest X-ray images using deep learning methods. International Journal of Environmental Research and Public Health. 2023; 20(3):1-13.

[31][31]Choudhary T, Gujar S, Goswami A, Mishra V, Badal T. Deep learning-based important weights-only transfer learning approach for COVID-19 CT-scan classification. Applied Intelligence. 2023; 53(6):7201-15.

[32][32]Albataineh Z, Aldrweesh F, Alzubaidi MA. COVID-19 CT-images diagnosis and severity assessment using machine learning algorithm. Cluster Computing. 2023:1-6.

[33][33]Ren K, Hong G, Chen X, Wang Z. A COVID-19 medical image classification algorithm based on transformer. Scientific Reports. 2023; 13(1):1-11.

[34][34]Mukhi SE, Varshini RT, Sherley SE. Diagnosis of COVID-19 from multimodal imaging data using optimized deep learning techniques. SN Computer Science. 2023; 4(3):1-9.

[35][35]Fan DP, Zhou T, Ji GP, Zhou Y, Chen G, Fu H, et al. Inf-net: automatic covid-19 lung infection segmentation from CT images. IEEE Transactions on Medical Imaging. 2020; 39(8):2626-37.

[36][36]Bougourzi F, Distante C, Dornaika F, Taleb-ahmed A. PDAtt-Unet: pyramid dual-decoder attention Unet for Covid-19 infection segmentation from CT-scans. Medical Image Analysis. 2023; 86:1-12.

[37][37]Chen H, Jiang Y, Ko H, Loew M. A teacher–student framework with fourier transform augmentation for COVID-19 infection segmentation in CT images. Biomedical Signal Processing and Control. 2023; 79:1-9.

[38][38]Chen C, Zhou K, Zha M, Qu X, Guo X, Chen H, et al. An effective deep neural network for lung lesions segmentation from COVID-19 CT images. IEEE Transactions on Industrial Informatics. 2021; 17(9):6528-38.

[39][39]Selvaraj D, Venkatesan A, Mahesh VG, Joseph RAN. An integrated feature frame work for automated segmentation of COVID‐19 infection from lung CT images. International Journal of Imaging Systems and Technology. 2021; 31(1):28-46.

[40][40]Ter-sarkisov A. Detection and segmentation of lesion areas in chest CT scans for the prediction of COVID-19. Science in Information Technology Letters. 2020; 1(2):92-9.

[41][41]Badrinarayanan V, Kendall A, Cipolla R. Segnet: a deep convolutional encoder-decoder architecture for image segmentation. IEEE Transactions on Pattern Analysis and Machine Intelligence. 2017; 39(12):2481-95.

[42][42]Ghosh S, Das N, Das I, Maulik U. Understanding deep learning techniques for image segmentation. ACM Computing Surveys. 2019; 52(4):1-35.

[43][43]Hossain MB, Iqbal SH, Islam MM, Akhtar MN, Sarker IH. Transfer learning with fine-tuned deep CNN ResNet50 model for classifying COVID-19 from chest X-ray images. Informatics in Medicine Unlocked. 2022; 30:1-10.

[44][44]Saood A, Hatem I. COVID-19 lung CT image segmentation using deep learning methods: U-Net versus SegNet. BMC Medical Imaging. 2021; 21(1):1-10.

[45][45]Enshaei N, Oikonomou A, Rafiee MJ, Afshar P, Heidarian S, Mohammadi A, et al. COVID-rate: an automated framework for segmentation of COVID-19 lesions from chest CT images. Scientific Reports. 2022; 12(1):1-18.

[46][46]Das A. Adaptive UNet-based lung segmentation and ensemble learning with CNN-based deep features for automated COVID-19 diagnosis. Multimedia Tools and Applications. 2022; 81(4):5407-41.

[47][47]Xiao H, Ran Z, Mabu S, Li Y, Li L. SAUNet++: an automatic segmentation model of COVID-19 lesion from CT slices. The Visual Computer. 2022:1-4.